Optical
Imaging
Light-based
imaging has extensive applications for medicine and biology, and recent advances
in optical imaging modalities, such as confocal and multi-photon scanning
fluorescence microscopy, bioluminescence, optical coherence tomography, and
spectral imaging have opened new avenues for visualizing and recording over
time, dynamic changes in genetic, developmental, and disease mechanisms that
cannot be captured by conventional light microscopy.
Using
molecular approaches in combination with optical imaging techniques, we establish gene expression profiles for early and advanced-stage melanomas and precursor
lesions; capture and record, noninvasively and in
real time, gene functions in melanoma xenografts; and image atypical nevi in patients with a
clinical history of melanoma to detect melanoma arising in these precursor
lesions.
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